Saleh A. Almatroodi
Bioactive Compounds of Garlic: Role in The Management of Various Types of Cancer
DOI URL: https://doi.org/10.46424/pharmanest.11.1.2020.1-13
Keywords: Allicin, Diallyl sulfide, Diallyl disulfide, Cancer
Allium Sativum L., well known as garlic, a member of the family Liliaceae, is one of the most commonly used spice and plant-based medicine worldwide. The health promoting effects of allicin, diallyl sulfide, diallyl disulfide and diallyl trisulfide, the principal active component of garlic has been established through its antioxidant potential. Moreover, bioactive compounds of garlic have shown their therapeutic implications in chemically induced carcinogenesis in animal models through suppression or inhibition of promotion and progression of carcinogenesis. Moreover, bioactive compound has revealed chemopreventive effect on various types of tumour including breast, liver, skin, pancreas, oral and prostate through inhibiting the cell proliferation. This review summarizes the mechanism of action and anti-cancerous effects of allicin, ajoene, diallyl sulfide, diallyl disulfide and diallyl trisulfide on different types of cancer. Further studies based on animal model are warranted to evaluate the efficacy, safety and mechanism of action of bioactive compound in tumour management.
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