Pages: 1539-1557
Date of Publication: 01-Dec-2013
FORMULATION AND IN-VITRO EVALUATION OF BOSENTAN MONOHYDRATE MICROSPHERES
Author: M.DIVYA*, Mrs.CH.S.VIJAYA VANI, Dr.V.UMAMAHESHWAR RAO
Category: Pharmaceutical Sciences
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Abstract: The present study performed by Formulation and Evaluation of microspheres of Bosentan monohydrate which is an anti-hypertensive drug. Microspheres were formulated with various materials like HPMC K4M, HPMC K15M, HPMC K100M, Carbopol 934P as rate controlling polymers. The microspheres were prepared by Solvent evaporation method. The variant proportion of the polymers HPMC K100M, Carbopol showed significant difference in the release rates. The drug release rate decreased as the concentration of carbopol is increased.
Keywords: Bosentan monohydrate, microspheres, antihypertensive, solvent evaporation method.
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