Pages: 1314-1321
Date of Publication: 01-Dec-2013
SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION FOR NAPROXEN AND RIZATRIPTAN IN BULK AND TABLET DOSAGE FORM USING ABSORPTION RATIO METHOD
Author: DINAKARAN SATHIS KUMAR*, ANUSHA POTHULA, DURGANAGA PRASHANTHI BOTLA, HAREESH KUMAR PASINIBILLI, AVASARALA HARANI, RAVISHANKAR K
Category: Pharmaceutical Sciences
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Abstract: A simple, economic and accurate absorption ratio method was developed for the simultaneous estimation of Naproxen (NAP) and Rizatriptan (RIZ) in bulk and tablet dosage form.Phosphate Buffer pH 7.4 was used as a diluent. The absorptions were observed at 216.34nm and 230.19nm which were selected based on overlap spectra of NAP and RIZ. The Linearity range was found to be 2-4.5 g/ml (r2 =0.9905) at 216.34nm and (r2 = 0.9998) at 230.19nm. The proposed method was validated. The reports was expressed that the proposed method was found to be simple, precise, accurate and rapid for the simultaneous estimation of NAP and RIZ in bulk and tablet dosage form using absorption ratio method.
Keywords: Absorption ratio, Naproxen, Phosphate Buffer pH 7.4, Rizatriptan
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