Pages: 1284-1293
Date of Publication: 01-Dec-2013
EVALUATION OF IN-VITRO ANTI-UROLITHIATIC ACTIVITY OF PORTULACA OLERACEA L
Author: KUMKUM AGARWAL*, RANJANA VARMA
Category: Pharmaceutical Sciences
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Abstract: The inhibition of in-vitro calcium-oxalate crystal formation by Portulaca oleracea L. extract was investigated by different methods i.e nucleation assay and synthetic urine assay. In nucleation assay, the aim was to evaluate the effectiveness of the extract on calcium oxalate crystallization in vitro while in synthetic urine method the percentage inhibition and growth of the COM crystals of oxalate from synthetic urine at different concentrations of extract was investigated. In nucleation assay % inhibition for CaOx crystal formation was found directly proportional to the increase in concentration of the plant extract with maximum inhibition of 71.07%, while in synthetic urine assay maximum inhibition was 79.31 %. Thus Portulaca oleracea L. was found to be a potent anti-urolithiatic agent.
Keywords: Urolithiasis, calcium oxalate (CaOx), calcium oxalate monohydrate (COM), Portulaca oleracea L. (PO), in-vitro
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