BOGA.SHALINI KRISHNA*, Dr.V.UMA MAHESWARA RAO, K.MAHALASKHMI, K.SHRUTHI Floating microspheres, Gastroretentive drug delivery, Floating Drug Delivery Systems, Polymers 1602-1624 Volume 4, Issue 6 November - December 2013 Delivery of the drug at controlled release rate to the specific body site is of paramount importance in the health care system. Gastroretentive drug delivery system helps in increasing the retention of the drugs at the intestinal region which have narrow absorption window, low bioavailability etc. Therefore, different novel strategies have been undertaken for the designing of several Gastroretentive drug delivery systems including floating microspheres. Floating microspheres are one of the novel approaches which are specially gaining attention due to their wide applicability in the targeting of drugs to stomach. These floating microspheres have the advantage that they remain buoyant and distributed uniformly over the gastric fluid to avoid the vagaries of gastric emptying and release the drug for prolonged period of time. The polymers used in the Floating Drug Delivery Systems are mainly involved in controlled release of drug from the delivery system which shows better results on selection of proper polymers and in their optimization. This article mainly emphasis on development techniques, effect of polymers on floating microspheres, characterization and applications.