CH. DEVADASU*,P. RAVISANKAR, P. SRINIVASA BABU, S.GANANADHAMU,S. SOWJANYA Silodosin, Reversed Phase HPLC, Validation, Dissolution testing 1479-1491 Volume 4, Issue 6 November - December 2013 Assay of Silodosin in capsule formulation was done by two ultraviolet spectrophotometric and one isocratic RP-HPLC method. The wavelength of maximum absorption for Silodosin in water was found at 268nm (method-I).The area under the absorption curve was recorded between 263nm and 273nm for each solution (method-II). A reversed phase column C18 (250 x 4.6 mm, 5m particle size), mobile phase consisting of phosphate buffer pH 3.2: Acetonitrile (60:40v/v) with a flow rate 1.0 mL/min. was used. The effluents of the column were monitored through a variable wavelength UV detector at 230nm (method-III). The proposed methods obeys linearity in the range of 10-60 g/mL and 4-20 g/mL for method-I, II and method-III respectively with correlation coefficient values above 0.999. The % RSD was found to be less than 2.0.The mean recoveries were found in the range of 97.50- 99.75%. Validation of the developed methods was performed in terms of accuracy, precision, linearity, etc. The proposed HPLC method has been applied to dissolution testing of the formulation.