KANWAL WASEEM KHAN, SYED WASEEMUDDIN AHMED, SALMAN AHMED* Luffa cylindrica, analgesic activity, analgesy meter test, mechanically induced pain 1401-1408 Volume 4, Issue 6 November - December 2013 Ethanol extracts of leaves, male flowers and fruit peel of Luffa cylindrica (L.) Roem., were evaluated for analgesic effect using analgesy meter test, a mechanically induced pain model. Extracts at the dose of 500 mg/kg, p.o., were tested and compared with diclofenac sodium 50mg/kg as standard analgesic drug. Mechanical force was applied on the rat paw and continuously increased. The point at which rat cant bear further pressure and starts struggle to free paw was taken as nociceptive response. Readings were taken before and after 1, 2 and 3hr following drug administration. Analgesic response was continuously increasing till 3hrs. Tested extracts produced significant and comparable analgesic effect as with diclofenac sodium.