SWARUPA ARVAPALLY*, AJAY KUMAR.B, Dr.V.UMAMAHESHWAR RAO, R.SHIREESH KIRAN, SAI SUPRAJA Ciprofloxacin HCL, floating bioadhesive tablets, flouroquinolone antibiotic 1332-1339 Volume 4, Issue 6 November - December 2013 The present study performed by Formulation and Evaluation of Floating Bioadhesive Tablets of Ciprofloxacin HCl as a model drug for prolongation of gastric residence time. Floating Bioadhesive tablets were formulated with various materials like Xanthangum and Guargum,Chitosan at varying concentrations were used for release controlling properties, sodium bicarbonate act as a effervescent agent and Lactose is used as Diluent. The tablets were prepared by direct compression technique and the prepared tablets remained buoyant for more than 12 hours in the released medium and showed good Bioadhesion Strength. The variant proportion of the polymers Xanthangum and Guargum, Chitosan showed significant difference in the release rate, buoyancy, bioadhesive strength and lag of the tablet.