K. SUJATHA*, J.V.L.N. SESHAGIRI RAO : Citalopram, Estimation, Tablets, HPLC 1299-1306 Volume 4, Issue 6 November - December 2013 An accurate high performance liquid chromatographic method was developed for quantification of citalopram in its tablet dosage forms. Ideal separation of the drug was achieved on an Agilent Eclipse XDB C18 column (150 x 4.6 mm; 5) by eluting with a mobile phase consisting of a mixture of acetate buffer (pH 4.5) and acetonitrile (65:35 v/v) at a flow rate of 1.0 mL/min. The drug in the eluates was monitored by U V detection at 240 nm. Under optimized conditions, the retention time obtained for the drug was 3.72 min. The relevant calibration plot was linear in the concentration range of 25-150 g/mL of the drug. The validation of the method was done by following the ICH guidelines. The proposed method could be applied for determination of citalopram in its tablet dosage forms without any interference from normal excipients. The method thus, is suitable for routine quality control analysis of citalopram.