SUDARSINI SARAVANABHAVAN*, FAHAD I. AL-SAIKHAN Cissus quadrangularis, Anti-ulcer, Histopathology, Hydroalcohol 1142-1151 Volume 4, Issue 6 November - December 2013 The hydroalcoholic extract of Cissus quadrangularis stem was investigated to evaluate its anti-ulcer activity by using aspirin induced gastric ulcer model, since non-steroidal anti-inflammatory drugs such as aspirin causes gastrointestinal damages as one of their side effects in human. The hydroalcoholic extract of Cissus quadrangularis stem was administered at the dose of 1000 mg/Kg.b.w to the groups of wistar rat orally for 7 consecutive days, after which gastric ulcer was induced by aspirin. Gross pathological examination reveals that Cissus quadrangularis promotes ulcer protection by decreasing the ulcer index which is evident in the Histopathological observation and qualitative analysis of C-reactive protein