MITRA M, SHIVALINGEGOWDA KP* Triphala, cardiotoxicity, catalase, lactate dehydragenase, electrocardiogram 1131-1141 Volume 4, Issue 6 November - December 2013 The objective was to evaluate the cardioprotective activity of triphala in doxorubicin induced cardiotoxicity in albino wistar rats. Twenty- four rats were divided into four groups (n=6). Group I (normal) received normal saline (p.o.) for 10 days. The group II rats received doxorubicin HCl (15mg/kg, i.p.) on 7th day. The rats in group III and IV were pretreated with triphala (500mg/kg, p.o. and 1000 mg/kg, p.o.) followed by doxorubicin on 7thday. On 11th day, ECG studies, serum creatinine phosphokinase (CPK), CK-MB and lactate dehydrogenase (LDH) levels as well as anti-oxidant parameters like superoxide dismutase, catalase and lipid peroxidation along with histopathological changes were studied. The doxorubicin treated rats have shown abnormal ECG values along with elevated (*** P