• ISSN : 2231 - 0541 (Online)
  • 0976 - 3090 (print)
  • NLM ID : 101613942
  • CAS CODEN : PHARN8
  • Frequency : Bi-Monthly

VALIDATED RP-HPLC METHOD FOR THE ESTIMATION OF SOLIFENACIN SUCCINATE IN TABLET DOSAGE FORMS

VALIDATED RP-HPLC METHOD FOR THE ESTIMATION OF SOLIFENACIN SUCCINATE IN TABLET DOSAGE FORMS

A rapid and reproducible reverse phase high performance liquid chromatographic method has been proposed for the estimation of Solifenacin. HPLC separation was carried out on a Symmetry C18 Xterra column (150 x 4.6mm; 5?) using a mobile phase composed of methanol and potassium dihydrogen phosphate buffer (65:35 v/v), which was pumped at a flow rate of 0.6 mL/min. The drug in the eluate was monitored at 210 nm. Under optimized conditions, the retention time obtained for the drug was 2.7 min. The method showed linear responses in the concentration range of 30 to 70 ?g/mL of Solifenacin succinate. The method was found to be giving reproducible recoveries of the drug from its tablet dosage forms.