• ISSN : 2231 - 0541 (Online)
  • 0976 - 3090 (print)
  • NLM ID : 101613942
  • CAS CODEN : PHARN8
  • Frequency : Bi-Monthly

REVIEW ON ANTI-MICROBIAL ACTIVITY OF SOME MANNICH BASE AND SCHIFF BASE OF ISATIN DERIVATIVES

REVIEW ON ANTI-MICROBIAL ACTIVITY OF SOME MANNICH BASE AND SCHIFF BASE OF ISATIN DERIVATIVES

Isatin has display moderate antimicrobial effect in a wide variety of preclinical antimicrobial models.
Isatin is also exerting other biological activities such as anticonvulsant activity, cytotoxic activity,
antifungal activity etc. Isatin and its analogs are versatile substrates, which can be used for the
synthesis of numerous heterocyclic compounds. Investigation of antimicrobial properties were done
against microbes such as S.aureus, B.subtilis, S.typhi E.coli, A.niger , C.albicans etc by paper-diskplate
technique (disk diffusion methods) and/or tube dilution technique using antibiotics such as
amoxicillin, fluconazole etc as standard drugs. Substitution of isatin at 3-position with substituted
phenyl ring is conductive for anti-microbial activity compaired to an unsubstituted phenyl group or
no substitution at the same position of isatin. Isatin derivatives are used in evaluating new product
that possesses different biological activities.