• ISSN : 2231 - 0541 (Online)
  • 0976 - 3090 (print)
  • NLM ID : 101613942
  • CAS CODEN : PHARN8
  • Frequency : Bi-Monthly

RECENT TRENDS ON CONTROLLED RELEASE PREPARATION OF ANTI-EPILEPTIC DRUGS

RECENT TRENDS ON CONTROLLED RELEASE PREPARATION OF ANTI-EPILEPTIC DRUGS

In the past few decades considerable interest has been shown in the advancement of drug delivery
systems. Research has been carried out to overwhelm the shortcomings of immediate release
preparations. As a result, the concept of novel drug delivery system has come out which provides
desired concentration of drug in the system for a long period to a target site. The research scientists
are usually using different polymers as wall materials and various types of preparation procedures
like, spray-drying and spray-congealing, solvent-evaporation, solid-dispersion, supercritical fluid
technology, polymerization, gelation technique etc. for designing such extended release formulations.
The diseases like epilepsy, diabetes, cancer, arthritis etc. require long term therapy and as a result
repeated administration of immediate release preparation for long time leads to various untoward
effects. Epilepsy is a chronic CNS disorder resulting from abnormal, excessive or hyper synchronous
neuronal activity in the brain and sometimes associated with recurrent and unprovoked seizure.
Though several anti-epileptic drugs (AED) are available but complete control of seizures with the
existing conventional dosage forms of these drugs are in question because of their side effects and
thus poor adherence to anti-epileptic drug therapy for long period. A number of research works have
pointed out that the sustained release preparations of AEDs may be beneficial over conventional
immediate release preparations with respect to delivery, bioavailability, release profile, toxicity, target
specificity etc. The objective of our present study is thus to highlight the recent research work
undertaken on controlled release preparation of available anti-epileptic drugs.