• ISSN : 2231 - 0541 (Online)
  • 0976 - 3090 (print)
  • NLM ID : 101613942
  • CAS CODEN : PHARN8
  • Frequency : Bi-Monthly

FORMULATION AND IN-VITRO CHARACTERIZATION OF VERAPAMIL HCL SUSTAINED RELEASE MATRIX TABLETS

FORMULATION AND IN-VITRO CHARACTERIZATION OF VERAPAMIL HCL SUSTAINED RELEASE MATRIX TABLETS

The objective of the present research work was to develop sustained release matrix tablets for Verapamil hydrochloride using different polymers, which causes patient compliance as the dosing frequency is reduced. The tablets were prepared by employing wet granulation method using various natural and synthetic polymers, such as sodium alginate, HPMC, Eudragit L100, Povidone, microcrystalline cellulose, magnesium stearate, in different ratios. The prepared sustained tablets were evaluated for the micromeretic properties such as bulk density , tapped density, Hausner’s ratio, compressibility index, angle of repose and post compression studies like weight uniformity test ,hardness ,friability ,thickness and diameter content uniformity, wetting and swelling studies , disintegration studies, drug content determination, excipients compatibility studies, In vitro dissolution studies which were performed using USP apparatus II (paddle method) over a period of 6 hours in 0.1N HCl and in pH 6.8 buffer for 6 hours. Prepared sustained release tablets which were subjected for in – vitro dissolution studies showed percentage drug release values which ranges from 49.52 - 93.599 %. Results concluded that there were no significant shifts in the peaks corresponding to the drug or polymers were observed in the formulation matrix. It was obsreved that formulation VP3 and VP5 was selected as the best formulation compare to all the prepared formulations.