• ISSN : 2231 - 0541 (Online)
  • 0976 - 3090 (print)
  • NLM ID : 101613942
  • CAS CODEN : PHARN8
  • Frequency : Bi-Monthly

FORMULATION AND EVALUATON OF ORAL DISINTEGRATING TABLETS OF CETIRIZINE HYDROCHLORIDE

FORMULATION AND EVALUATON OF ORAL DISINTEGRATING TABLETS OF CETIRIZINE HYDROCHLORIDE

Oral disintegrarion tablets of Cetirizine Hydrochloride were prepared by direct compression method using different super disintegrating agents such as Crosspovidone, Sodium starch glycolate and Crosscarmellose sodium. An optimized formulation F8( low hardness) was found, which provided short wetting time of 74sec and water absorption ratio of 16.24sec, In-vitro disintegration time of 55sec and In-vitro % drug release 98.75 in time of 15min. It indicated that the amount of Super disintegrant Cross carmellose sodium significantly affected the dependent variables like wetting time, water absorption ratio, In-vitro disintegration time and In-vitro dispersion time. The best In-vitro drug release was found to be in formulation F8 (hh) low hardness 98.75% drug release during the end of 15min.