• ISSN : 2231 - 0541 (Online)
  • 0976 - 3090 (print)
  • NLM ID : 101613942
  • CAS CODEN : PHARN8
  • Frequency : Bi-Monthly

FORMULATION AND EVALUATION OF SIMVASTATIN FAST DISSOLVING TABLETS

FORMULATION AND EVALUATION OF SIMVASTATIN FAST DISSOLVING TABLETS

Fast dissolving tablets are the fast growing and highly accepted drug delivery system in now a day mainly to improve patient compliance. Fast dissolving tablets have number of advantages over conventional dosage forms, because of those fast dissolving tablets have emerged as an alternative to
conventional dosage forms. Fast dissolving tablets of Simvastatin were prepared using superdisintegrants viz; crospovidone, croscarmellose sodium and sodium starch glycolate using direct compression technique. The tablets prepared were evaluated for thickness, uniformity of weight,
hardness, friability, wetting time, in vitro disintegration time and in vitro dissolution time. The different formulations showed disintegration time between 60 to 130 s. Drug release was between the time ranges of 30 to 60 min. Among all the formulations, F9 (containing 6% of Sodium starch glycolate) showed 99% drug release within 30 min and it showed least disintegration time (60s). Thus,F9 was considered best among the formulations and compared with tablet prepared with different technique (granulation) and marketed formulation and F9 was best among all the formulations