• ISSN : 2231 - 0541 (Online)
  • 0976 - 3090 (print)
  • NLM ID : 101613942
  • CAS CODEN : PHARN8
  • Frequency : Bi-Monthly

DESIGNING AND CHARACTERIZATION OF CHLORPHENERAMINE MALEATE TRANSDERMAL PATCHES

DESIGNING AND CHARACTERIZATION OF CHLORPHENERAMINE MALEATE TRANSDERMAL PATCHES

Transdermal drug delivery system (TDDS) provides a means to sustain drug release as well as reduce
the intensity of action and thus reduce the side effects associated with its oral therapy. In the present
study, an attempt was made to develop a suitable matrix type transdermal patch of Chlorpheniramine
maleate with different ratios of polymeric systems of agar, acacia, polyvinyl alcohol, polyvinyl
pyrrolidone, Eudragit RS 100 by solvent evaporation technique by using glycerin and polyethylene
glycol as plasticizer for improvement of bioavailability of drug. The physicochemical compatibility of
the drug and the polymers studied by infrared spectroscopy suggested absence of any incompatibility.
Formulated transdermal films were physically evaluated with regard to thickness, weight variation,
drug content, flatness, tensile strength, folding endurance, percentage of moisture content and water
vapor transmission rate. The in vitro release of the drug from the formulations was studied using
goat skin as a semi-permeable membrane and CM7 shown the maximum response. From the In vitro
dissolution data showed that formulation CM7 showed the better release of the drug than the other polymers
combinations. Hence CM7 is the best formulation among the various formulation used in this
research work.