• ISSN : 2231 - 0541 (Online)
  • 0976 - 3090 (print)
  • NLM ID : 101613942
  • CAS CODEN : PHARN8
  • Frequency : Bi-Monthly

ANTITHROMBOTIC AND THROMBOLYTIC ACTIVITY OF NIGELLA SATIVA SEED EXTRACTS

ANTITHROMBOTIC AND THROMBOLYTIC ACTIVITY OF NIGELLA SATIVA SEED EXTRACTS

Thrombolytic agents are used to dissolve the preformed clots in the blood vessels. However, the available drugs have certain limitations such as allergic reactions and expensive. The aim of the present study was to investigate whether preparations of Nigella sativa seeds possess thrombolytic and antithrombotic activity. An in vitro model was used to check the thrombolytic and antithrombotic effect of Nigella sativa seeds against Streptokinase as a positive control. It was found that after addition of Streptokinase, clot formation is delayed upto more than 90 min. Different concentrations of Nigella setiva extract delayed the clot formation. The maximum delay in the clot formation of 27 min was recorded at 1.00 mg/dl. For thrombolytic activity, at this concentration the clot dissolution time was 79 min with aqueous extracts. Although in present study, we found that Nigella sativa seeds possess thrombolytic and antithrombotic activity but in vivo clot dissolving properties and active component of Nigella sativa for clot lysis are to be studied.