• ISSN : 2231 - 0541 (Online)
  • 0976 - 3090 (print)
  • NLM ID : 101613942
  • CAS CODEN : PHARN8
  • Frequency : Bi-Monthly

ADAPTOGENIC ACTIVITY OF ETHANOLIC EXTRACT OF EMBLICA OFFICINALIS FRUITS

ADAPTOGENIC ACTIVITY OF ETHANOLIC EXTRACT OF EMBLICA OFFICINALIS FRUITS

Emblica officinalis is a plant with diverse ethnical medicinal uses. The plant has been explored for diverse pharmacological actions, here it is planned to screen fruit extract for Adaptogenic activity. Wistar rats were subjected to acute physical stress (forced swimming endurance stress) to gauge the antistress potential of the extract. Stimulation of hypothalamus pituitary adrenal axis in stressful condition alters plasma glucose, triglyceride, cholesterol, SGPT and SGOT. There is also alteration in locomotor movement and blood cell counts. Pretreatment with extract significantly ameliorated the stress-induced variations in these biochemical levels and blood cell counts in acute stress model. The extract treated animals showed increase in swimming endurance time. Treatment groups also reverted back increase in liver, brain, kidney, adrenal gland weights and atrophy of spleen caused by swimming endurance stress model. The results indicate that Ethanolic extract of Emblica officinalis has significant Adaptogenic activity against variety of biochemical and physiological perturbations.