• ISSN : 2231 - 0541 (Online)
  • 0976 - 3090 (print)
  • NLM ID : 101613942
  • CAS CODEN : PHARN8
  • Frequency : Bi-Monthly

A VIEW ON “ADVANCED SELF EMULSIFYING LIPID FORMULATIONS (SELFs)” IN ENHANCING THE AQUEOUS SOLUBILITY OF HYDROPHOBIC DRUGS

A VIEW ON “ADVANCED SELF EMULSIFYING LIPID FORMULATIONS (SELFs)” IN ENHANCING THE AQUEOUS SOLUBILITY OF HYDROPHOBIC DRUGS

It has been estimated that 40% of active new chemical entities (NCEs) identified in combinatorial screening programs employed by many pharmaceutical companies are poorly water-soluble and not well absorbed after oral administration which can distract from the drugs inherent efficacy. Various techniques have been developed for the improvement of solubility of poorly aqueous soluble drugs. Recently, self-emulsifying lipid formulations (SELFs) are considered a relatively newer strategy. SELFs is a drug delivery system that uses micro emulsion achieved by chemical rather than mechanical means. SELFs consist of lipids, surfactants, co solvents. The unique properties of lipids and their proven ability to formulate poorly-water soluble molecules may have a remarkable impact on enhancing bioavailability of drugs eliminating food effects, allowing for dose escalation and thereby improving efficacy and safety. This article focused on the advanced formulations of SELFs with recent literature reports and some patented formulations have also been highlighted.